Increased expression of efflux pump genes in extensively drug-resistant isolates of Mycobacterium tuberculosis
نویسندگان
چکیده
منابع مشابه
Effect of efflux pump inhibitors on drug susceptibility of ofloxacin resistant Mycobacterium tuberculosis isolates
BACKGROUND & OBJECTIVES In drug resistant, especially multi-drug resistant (MDR) tuberculosis, fluoroquinolones (FQs) are used as second line drugs. However, the incidence of FQ-resistant Mycobacterium tuberculosis is rapidly increasing which may be due to extensive use of FQs in the treatment of various other diseases. The most important known mechanism i.e., gyrA mutation in FQ resistance is ...
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Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 13, No. 9, September 2007 1429 niazid chemoprophylaxis due to resistance of the infecting organism. Decreased susceptibility to isoniazid among M. kansasii isolates is common (7,8), and this microorganism is naturally resistant to pyrazinamide (9). This pattern of resistance is a serious obstacle for the use of these drugs in monotherapy or ...
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متن کاملAntitubercular activity of disulfiram, an antialcoholism drug, against multidrug- and extensively drug-resistant Mycobacterium tuberculosis isolates.
The antimycobacterial activities of disulfiram (DSF) and diethyldithiocarbamate (DDC) against multidrug- and extensively drug-resistant tuberculosis (MDR/XDR-TB) clinical isolates were evaluated in vitro. Both DSF and DDC exhibited potent antitubercular activities against 42 clinical isolates of M. tuberculosis, including MDR/XDR-TB strains. Moreover, DSF showed remarkable bactericidal activity...
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ژورنال
عنوان ژورنال: International Journal of Mycobacteriology
سال: 2016
ISSN: 2212-5531
DOI: 10.1016/j.ijmyco.2016.09.067